A promoter in a transcription of an adhesion protein has become the first known example of an enzyme that gives rise to a natural biological process.
Key points:The discovery has scientists at Wageningen University in the Netherlands looking at the role of adhesion in the formation of new proteins.
The enzyme was first identified in humans in 2012, but its role in the development of new cells is still unclear.
The discovery, published in Nature, was based on a DNA-sequencing technique that could tell whether a protein had been created in the lab or in the cell by measuring its presence in the RNA.
Researchers from Wageningens University’s Institute of Molecular Biology and Biotechnology (IMB) and the University of Groningen’s Institute for Molecular Biology (IMBG) sequenced the enzyme using a method called tandem-repeat PCR.
They found that the enzyme was made in the laboratory, and was present in all cells from a mouse strain that had been engineered to be unable to form adhesion.
They also found that, in the mouse, the enzyme had been found in only four out of six copies of the protein that it was found in.
It’s unclear why this particular enzyme was formed, but the researchers are now working to determine whether it is an essential enzyme in the process of making new proteins or simply a by-product of the process.
“In our laboratory, we have already observed that adhesion is an important process for the creation of new molecules,” Dr Robert Van der Zyl, the first author of the study, said.
“We can now begin to understand what is going on in this process in other organisms.”
This is an exciting and exciting discovery, because it gives us a new avenue to explore what happens in the cells of the body in the same way that we can observe in cells in our body.
“The discovery of the enzyme comes from the work of Dr Thomas Van der Laan, a professor at Wagens University who has been studying adhesion since 2013.
He is also a member of the team that discovered adhesion, but has never before studied the enzyme itself.
He said the discovery was important because it gave scientists a better understanding of how adhesion happens in a cell.”
What we were doing before was studying the enzyme in an in vitro environment, and this is the first time that we have seen in the real world what is happening in a living organism,” Dr Van der Laug said.
The study was funded by the Australian Research Council (ARC), the Netherlands Organisation for Scientific Research (NOSR), the European Union and the Netherlands Ministry of Education and Research.
It was published in the journal Nature.